Motor learning has been associated with changes in GABA concentration in the motor cortex (M1) (Floyer-Lea et al. 2006) and GABAergic medication can disrupt the learning process (Donchin et al. 2002; Bütefisch et al. 2000). Indeed, a decrease in GABA concentration appears to be crucial for motor cortex reorganization elicited by motor learning (Jacobs & Donoghue 1991).
In the paper that I'll write about in this post, Charlotte Stagg and her colleagues from Oxford tested the hypothesis that the responsiveness of the GABA system correlated with the amount of motor learning across individuals (Stagg et al. 2011). In other words, if your brain can easily drive your GABA concentration down, can you learn faster or better a new motor task?